… selectivity and acquired resistance remains elusive. In an effort to … acquired PDX resistance,
we generated resistant cells lines over a broad concentration range. PDX-resistant cell lines …

… exhibit intrinsic resistance or develop acquired resistance. … Gene set enrichment analysis
revealed that adipogenesis … PDX-resistant T-cell acute lymphoblastic leukemia cell lines, and …

… shows common epigenetic mutations, targets, and the drugs … a classical epigenetic modifier,
pralatrexate was the first drug … -generation epigenetic modifiers and other new drugs has the …

… a second-generation analog of vorinostat, belinostat (PXD101) shows … inhibitor pralatrexate
[89] have been demonstrated in T-cell … It acquired approval from the China Food and Drug …

… The novel genetic information gained from genome-wide high-… Next-generation functional
drug screening (ngFDS) aims to … A phase 1 study of romidepsin and pralatrexate reveals …

… synthase as well as pralatrexate which blocks dihydrofolate … for the development of the
next generation antifolates. Pre-… membrane topology of PCFT reveals 12 TMDs with a large …

… in the 1980s by studies that revealed recurrent chromosomal … By generating an efflux pump
mechanism for … studies, the most promising appear to be romidepsin/pralatrexate (ORR 71%; …

… differentiation potential and the acquisition of functional traits. … Next-generation sequencing
has revealed recurrent genetic … and refractory PTCL-NOS: pralatrexate, the HDAC inhibitors …

… However, recent advances in next-generation sequencing, gene expres… Indeed, in vitro
testing has established that pralatrexate … or refractory lymphoma reveals marked activity in T-cell …

… (Tomudex) and pralatrexate are structural folate antagonists of … pralatrexate are known to
inhibit TS as their primary drug … related to drug toxicity and the development of drug resistance, …